研究業績

  1.  Kuba K*, Yamaguchi T, Penninger JM. Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19. Front. Immunol., 12:732690, 2021. doi.org/10.3389/fimmu.2021.732690.
  2. Fujita H, Motoyama S, An J, Nagakai Y, Yamaguchi T, Koyota S, Sato Y, Wakita A, Imai K, Kuba K, Minamiya Y. Peritumoral CD16b positive-neutrophil accumulation strongly correlates with regional lymph node metastasis in thoracic esophageal squamous cell cancer. Surgery. S0039-6060(21)01170-3, 2022.
  3. Yamaguchi T, Hoshizaki M, Minato T, Nirasawa S, Asaka MN, Niiyama M, Imai M, Uda A, Chan JFW, Takahashi S, An J, Saku A, Nukiwa R, Utsumi D, Kiso M, Yasuhara A, Poon VKM, Chan CCS, Fujino Y, Motoyama S, Nagata S, Penninger JM, Kamada H, Yuen KY, Kamitani W, Maeda K, Kawaoka Y, Yasutomi Y, Imai Y, Kuba K*.  ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury. Nature Communications, 12(1):6791, 2021. doi: 10.1038/s41467-021-27097-8.
  4. Asaka MN, Utsumi D, Kamada H, Nagata S, Nakachi Y, Yamaguchi T, Kawaoka Y, Kuba K, Yasutomi Y. Highly susceptible SARS-CoV-2 model in CAG promoter-driven hACE2-transgenic mice. JCI Insight. 6(19):e152529, 2021. doi: 10.1172/jci.insight.152529.
  5. Kim KS, Iwanami S, Oda T, Fujita Y, Kuba K, Miyazaki T, Ejima K, Iwami S.  Incomplete antiviral treatment may induce longer durations of viral shedding during SARS-CoV-2 infection. Life Sci Alliance. 4(10):e202101049, 2021. doi: 10.26508/lsa.202101049.
  6. Shiimori M, Ichida Y, Nukiwa R, Sakuma T, Abe H, Kajitani R, Fujino Y, Kikuchi A, Kawamura T, Kodama T, Toyooka S, Shirahige K, Schotta G, Kuba K, Itoh T, Imai Y.  Suv4-20h2 protects against influenza virus infection by suppression of chromatin loop formation. iScience. 24(6):102660, 2021. doi: 10.1016/j.isci.2021.102660.
  7. Fujishima N, Kohmaru J, Koyota S, Kuba K, Saga T, Omokawa A, Moritoki Y, Ueki S, Ishida F, Nakao S, Matsuda A, Ohta A, Tohyama K, Yamasaki H, Usuki K, Nakashima Y, Sato S, Miyazaki Y, Nannya Y, Ogawa S, Sawada K, Mitani K, Hirokawa M.  Clonal hematopoiesis in adult pure red cell aplasia. Sci Rep. 11(1):2253, 2021. doi: 10.1038/s41598-021-81890-5.
  8. Nakashima A, Takeya M, Kuba K, Takano M, Nakashima N.  Virus database annotations assist in tracing information on patients infected with emerging pathogens. Inform Med Unlocked. 21:100442, 2020. doi: 10.1016/j.imu.2020.
  9. Ogawa M, Ishihara T, Isobe Y, Kato T, Kuba K, Imai Y, Uchino Y, Tsubota K, Arita M.  Eosinophils promote corneal wound healing via the 12/15-lipoxygenase pathway. FASEB J. 34(9):12492-12501, 2020. doi: 10.1096/fj.202000483R.
  10. Nagaki Y, Motoyama S, Yamaguchi T, Hoshizaki M, Sato Y, Sato T, Koizumi Y, Wakita A, Kawakita Y, Imai K, Nanjo H, Watanabe H, Imai Y, Minamiya Y, Kuba K*.  m6A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis. Genes Cells. 2020 May 25. doi: 10.1111/gtc.12792.
  11.  Takahashi A, Suzuki T, Soeda S, Takaoka S, Kobori S, Yamaguchi T, Mohamed HMA, Yanagiya A, Abe T, Shigeta M, Furuta Y, Kuba K, Yamamoto T*.  The CCR4-NOT complex maintains liver homeostasis through mRNA deadenylation. Life Science Alliance 3(5), pii: e201900494, 2020.
  12. Minato T, Nirasawa S, Sato T, Yamaguchi T, Hoshizaki M, Inagaki T, Nakahara K, Yoshihashi T, Ozawa R, Yokota S, Natsui M, Koyota S, Yoshiya T, Yoshizawa-Kumagaye K, Motoyama S, Gotoh T, Nakaoka Y, Penninger JM, Watanabe H, Imai Y, Takahashi S, Kuba K*. B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction. Nature Communications. 11(1):1058, 2020.
  13.  Mostafa D, Takahashi A, Yanagiya A, Yamaguchi T, Abe T, Kureha T, Kuba K, Kanegae Y, Furuta Y, Yamamoto T, Suzuki T.  Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability. RNA Biol. 17(3):403-416, 2020.
  14. Takahashi A, Takaoka S, Kobori S, Yamaguchi T, Ferwati S, Kuba K, Yamamoto T, Suzuki T. The CCR4-NOT deadenylase complex maintains adipocyte identity. Int J Mol Sci. 20(21), pii: E5274, 2019.
  15. Uribesalgo I, Hoffmann D, Zhang Y, Kavirayani A, Lazovic J, Berta J, Novatchkova M, Pai TP, Wimmer RA, László V, Schramek D, Karim R, Tortola L, Deswal S, Haas L, Zuber J, Szűcs M, Kuba K, Dome B, Cao Y, Haubner BJ, Penninger JM.  Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy. EMBO Mol Med. 11(8): e9266, 2019.
  16. Koizumi Y, Fukushima J, Kobayashi Y, Kadowaki A, Natsui M, Yamaguchi T, Imai Y, Sugiyama T, Kuba K*. Genome-Scale CRISPR/Cas9 Screening Reveals Squalene Epoxidase as a Susceptibility Factor for Cytotoxicity of Malformin A1. Chembiochem. 20(12):1563-1568, 2019.
  17. Sato T, Kadowaki A, Suzuki T, Ito H, Watanabe H, Imai Y, Kuba K*. Loss of Apelin augments Angiotensin II-induced cardiac dysfunction and pathological remodeling. International Journal of Molecular Sciences 20(2) pii: E239, 2019.
  18. Fujiwara S, Hoshizaki M, Ichida Y, Lex D, Kuroda E, Ishii KJ, Magi S, Okada M, Takao T, Gando M, Imai H, Hara R, Herzog H, Yoshimura A, Okamura H, Penninger JM, Slutsky AS, Uhlig S, Kuba K, Imai Y*. Pulmonary phagocyte-derived NPY and Y1 receptor axis controls the pathology of severe influenza virus infection. Nature Microbiology 4(2):258-268, 2018.
  19.  Kuba K*, Sato T, Imai Y, Yamaguchi T. Apelin and Elabela/Toddler; double ligands for APJ/Apelin receptor in heart development, physiology, and pathology. Peptides S0196-9781(18)30085-8, 2018.
  20.  Koizumi Y*, Nagai K, Gao L, Koyota S, Yamaguchi T, Natsui M, Imai Y, Hasumi K, Sugiyama T, Kuba K. Involvement of RSK1 activation in malformin-enhanced cellular fibrinolytic activity. Scientific Reports 88(1): 5472, 2018.
  21.  Yamaguchi T, Suzuki T#, Sato T, Takahashi A, Watanabe H, Kadowaki A, Natsui M, Inagaki H, Arakawa S, Nakaoka S, Koizumi Y, Seki S, Adachi S, Fukao A, Fujiwara T, Natsume T, Kimura A, Komatsu M, Shimizu S, Ito H, Suzuki Y, Penninger JM, Yamamoto T, Imai Y, Kuba K*. The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Science Signaling 11(516): eaan3638, 2018. (#: equal first author)
  22.  Freyer L, Hsu CW, Nowotschin S, Pauli A, Ishida J, Kuba K, Fukamizu A, Schier AF, Hoodless PA, Dickinson ME, Hadjantonakis AK*. Loss of Apela peptide in mice causes low penetrance embryonic lethality and defects in early mesodermal derivatives. Cell Reports 20(9): 2116-2130, 2017.
  23.  Rodríguez-Gil A, Ritter O, Saul VV, Wilhelm J, Yang CY, Grosschedl R, Imai Y, Kuba K, Kracht M, Schmitz ML*. The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription. Scientific Reports. 7 (1): 3547, 2017.
  24.  Sato T, Sato C, Kadowaki A, Watanabe H, Ho L, Ishida J, Yamaguchi T, Kimura A, Fukamizu A, Penninger JM, Reversade B, Ito H, Imai Y, Kuba K*.  ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage. Cardiovascular Research. 113 (7): 760-769, 2017.
  25.  Kimura H, Eguchi S, Sasaki J, Kuba K, Nakanishi H, Takasuga S, Yamazaki M, Goto A, Watanabe H, Itoh H, Imai Y, Suzuki A, Mizushima N, Sasaki T*. Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy. JCI Insight. 2 (1): e89462, 2017.
  26.  Tanaka KI*, Tamura F, Sugizaki T, Kawahara M, Kuba K, Imai Y, Mizushima T. Evaluation of Lecithinized Superoxide Dismutase for the Prevention of Acute Respiratory Distress Syndrome in Animal Models. Am J Respir Cell Mol Biol. 56 (2): 179-190, 2017.
  27.  Yang CY, Ramamoorthy S, Boller S, Rosenbaum M, Rodriguez Gil A, Mittler G, Imai Y, Kuba K, Grosschedl R*. Interaction of CCR4-NOT with EBF1 regulates gene-specific transcription and mRNA stability in B lymphopoiesis. Genes Dev. 30 (20): 2310-2324, 2016.
  28.  Koizumi Y, Nagai K, Hasumi K, Kuba K, Sugiyama T*. Structure-activity relationship of cyclic pentapeptide malformins as fibrinolysis enhancers. Bioorg Med Chem Lett. 26 (21): 5267-5271, 2016.
  29.  Sun Y, Guo F, Zou Z, Li C, Hong X, Zhao Y, Wang C, Wang H, Liu H, Yang P, Han Z, Liu K, Kuba K, Song B, Gao J, Mo Z, Li D, Li B, Li Q, Zhong N, Wang C, Penninger JM, Jiang C*. Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice. Particle and Fibre Toxicology 12: 4, 2015.
  30.  Demetz E, Schroll A, Auer K, Heim C, Patsch JR, Eller P, Theurl M, Theurl I, Theurl M, Seifert M, Lener D, Stanzl U, Haschka D, Asshoff M, Dichtl S, Nairz M, Huber E, Stadlinger M, Moschen AR, Li X, Pallweber P, Scharnagl H, Stojakovic T, März W, Kleber ME, Garlaschelli K, Uboldi P, Catapano AL, Stellaard F, Rudling M, Kuba K, Imai Y, Arita M, Schuetz JD, Pramstaller PP, Tietge UJ, Trauner M, Norata GD, Claudel T, Hicks AA, Weiss G, Tancevski I*.　The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism. Cell Metabolism 20: 787-98, 2014.
  31.  Morita M, Kuba K#, Ichikawa A, Nakayama M, Katahira J, Iwamoto R, Watanebe T, Sakabe S, Daidoji T, Nakamura S, Kadowaki A, Ohto T, Nakanishi H, Taguchi R, Nakaya T, Murakami M, Yoneda Y, Arai H, Kawaoka Y, Penninger JM, Arita M, Imai Y*.　The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. Cell 153: 112-125, 2013. (#: equal first author)
  32.  Ichikawa A, Kuba K#, Morita M, Chida S, Tezuka H, Hara H, Sasaki T, Ohteki T, Ranieri VM, dos Santos CC, Kawaoka Y, Akira S, Luster AD, Lu B, Penninger JM, Uhlig S, Slutsky AS, Imai Y*. CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. American Journal of Respiratory and Critical Care Medicine. 187: 65-77, 2013. (#: equal first author)
  33.  Sato T, Suzuki T, Watanabe H, Kadowaki A, Fukamizu A, Liu PP, Kimura A, Ito H, Penninger JM, Imai Y, Kuba K*. Apelin is a positive regulator of ACE2 in failing hearts. Journal of Clinical Investigation 123: 5203-5211, 2013.
  34.  Kuba K*, Imai Y, Penninger JM. Multiple functions of angiotensin-converting enzyme 2 and its relevance in cardiovascular diseases. Circulation Journal 77: 301-308, 2013.
  35.  Arimura T, Onoue K, Takahashi-Tanaka Y, Ishikawa T, Kuwahara M, Setou M, Shigenobu S, Yamaguchi K, Bertrand AT, Machida N, Takayama K, Fukusato M, Tanaka R, Somekawa S, Nakano T, Yamane Y, Kuba K, Imai Y, Saito Y, Bonne G, Kimura A*. Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations. Cardiovasc Res. 99:382-94, 2013.
  36.  Hashimoto T, Perlot T, Rehman A, Trichereau J, Ishiguro H, Paolino M, Sigl V, Hanada T, Hanada R, Lipinski S, Wild B, Camargo SM, Singer D, Richter A, Kuba K, Fukamizu A, Schreiber S, Clevers H, Verrey F, Rosenstiel P, Penninger JM*. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature 487: 477-481, 2012.
  37.  Attané C, Foussal C, Le Gonidec S, Benani A, Daviaud D, Wanecq E, Guzman-Ruiz R, Dray C, Bezaire V, Rancoule C, Kuba K, Ruiz-Gayo M, Levade T, Penninger J,M Burcelin R, Pénicaud L, Valet P, Castan-Laurell I*. Apelin treatment increases fatty acid oxidation, mitochondrial oxidative capacity and biogenesis in muscle of insulin-resistant mice. Diabetes 61: 310-320, 2012.
  38.  An J, Nakajima T, Kuba K, Kimura A*. PPARgamma-dependent mechanism in human THP-1 macrophages. Hypertension Research 33: 831-835, 2010.
  39.  Neely GG, Kuba K*#, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmén L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NN, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks AA, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM*. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell 141: 142-153, 2010. (#: equal first author)
  40.  Haubner BJ, Neely GG, Voelkl JG, Damilano F, Kuba K, Imai Y, Komnenovic V, Mayr A, Pachinger O, Hirsch E, Penninger JM, Metzler B*. PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway. PLoS One 22: e9350, 2010.
  41.  Isobe K, Kuba K, Maejima Y, Suzuki J, Kubota S, Isobe M*. Inhibition of endostatin/collagen XVIII deteriorates left ventricular remodeling and heart failure in rat myocardial infarction model. Circulation Journal 74: 109-119, 2010.
  42.  Kuba K*, Imai Y, Ohto-Nakanishi T, Penninger JM. Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters. Pharmacology & Therapeutics 128: 119-128, 2010.
  43.  Imai Y*, Kuba K, Ohto-Nakanishi T, Penninger JM. Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. Circulation Journal 74: 405-410, 2010.
  44.  Singer D, Camargo SM, Huggel K, Romeo E, Danilczyk U, Kuba K, Chesnov S, Caron MG, Penninger JM, Verrey F*. Orphan Transporter SLC6A18 Is Renal Neutral Amino Acid Transporter B0AT3. Journal of Biological Chemistry 284: 19953-19960, 2009.
  45.  Kishi Y, Kuba K, Nakamura T, Wen J, Suzuki Y, Mizuno S, Nukiwa T, Matsumoto K, Nakamura T*. Systemic NK4 gene therapy inhibits tumor growth and metastasis of melanoma and lung carcinoma in syngeneic mouse tumor models. Cancer Science 100: 1351-1358, 2009.
  46.  Camargo SM, Singer D, Makrides V, Huggel K, Pos KM, Wagner CA, Kuba K, Danilczyk U, Skovby F, Kleta R, Penninger JM, Verrey F*. Tissue-specific amino acid transporter partners ACE2 and Collectrin differentially interact with Hartnup mutations. Gastroenterology 136: 872-882, 2009.
  47.  Oudit GY*, Imai Y, Kuba K, Scholey JW, Penninger JM. The role of ACE2 in pulmonary diseases--relevance for the nephrologist. Nephrology Dialysis Transplantation 24: 1362-1365, 2009.
  48.  Imai Y, Kuba K, Neely GG, Yaghubian-Malhami R, Perkmann T, van Loo G, Ermolaeva M, Veldhuizen R, Leung YH, Wang H, Liu H, Sun Y, Pasparakis M, Kopf M, Mech C, Bavari S, Peiris JS, Slutsky AS, Akira S, Hultqvist M, Holmdahl R, Nicholls J, Jiang C, Binder CJ, Penninger JM*. Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell 133: 235-249, 2008.
  49.  Imai Y*, Kuba K, Penninger JM. The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice. Experimental Physiology 93: 543-538, 2008.
  50.  Kuba K, Zhang L, Imai Y, Arab S, Chen M, Maekawa Y, Leschnik M, Leibbrandt A, Markovic M, Schwaighofer J, Beetz N, Musialek R, Neely GG, Komnenovic V, Kolm U, Metzler B, Ricci R, Hara H, Meixner A, Nghiem M, Chen X, Dawood F, Wong KM, Sarao R, Cukerman E, Kimura A, Hein L, Thalhammer J, Liu PP, Penninger JM*. Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circulation Research 101: 32-42, 2007.
  51.  Imai Y*, Kuba K, Penninger JM. Renin angiotensin system and acute respiratory distress syndrome (ARDS). Drug Discovery Today 3: 225-229, 2007.
  52.  Imai Y*, Kuba K, Penninger JM. Angiotensin-converting enzyme 2 in acute respiratory distress syndrome. Cellular and Molecular Life Sciences. 64: 2006-2012, 2007.
  53.  Kuba K*, Imai Y, Penninger JM. Angiotensin converting enzyme 2 in lung diseases. Current Opinion in Pharmacology. 62: 271-276, 2006.
  54.  Kuba K*, Imai Y, Rao S, Jiang C, Penninger JM. Lessons from SARS: control of acute lung failure by the SARS receptor ACE2. Journal of Molecular Medicine 84: 814-820, 2006.
  55.  Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, Huan Y, Yang P, Zhang Y, Deng W, Bao L, Zhang B, Liu G, Wang Z, Chappell M, Liu Y, Zheng D, Leibbrandt A, Wada T, Slutsky AS, Liu D, Qin C, Jiang C, Penninger JM*. A critical role of angiotensin converting enzyme 2 (ACE2) in SARS pathogenesis. Nature Medicine 11: 875-879, 2005.
  56.  Imai Y#, Kuba K#, Rao S, Huan Y, Guo F, Guan B, Yang P, Sarao R, Wada T, Leong-Poi H, Crackower MA, Fukamizu A, Hui CC, Hein L, Uhlig S, Slutsky AS, Jiang C, Penninger JM*. Angiotensin converting enzyme 2 protects from severe acute lung failure. Nature 436: 112-116, 2005. (#: equal first author)
  57.  Nakabayashi M, Morishita R, Nakagami H, Kuba K, Matsumoto K, Nakamura T, Tano Y, Kaneda Y*. HGF/NK4 inhibited VEGF-induced angiogenesis in in vitro cultured endothelial cells and in vivo rabbit model. Diabetologia 46: 115-123, 2003.
  58.  Tomioka D, Maehara N, Kuba K, Mizumoto K, Tanaka M, Matsumoto K, Nakamura T*. Inhibition of growth, invasion and metastasis of human pancreatic carcinoma cells by NK4 in an orthotopic mouse model. Cancer Research 61: 7518-7524, 2001.
  59.  Maehara N, Matsumoto K, Kuba K, Mizumoto K, Tanaka M, Nakamura T*. NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells. British Journal of Cancer 84: 864-873, 2001.
  60.  Kuba K, Matsumoto K, Ohnishi K, Shiratsuchi T, Tanaka M, Nakamura T*. Kringle 1-4 of hepatocyte growth factor inhibits proliferation and migration of human microvascular endothelial cells. Biochemical and Biophysical Research Communications 279: 846-852, 2000.
  61.  Kuba K, Matsumoto K, Date K, Shimura H, Tanaka M, Nakamura T*. HGF/NK4, a four-kringle antagonist of hepatocyte growth factor, is an angiogenesis inhibitor that suppresses tumor growth and metastasis in mice. Cancer Research 60: 6737-6743, 2000.
  62.  Date K, Matsumoto K, Kuba K, Shimura H, Tanaka M, Nakamura T*. Inhibition of tumor growth and invasion by a four-kringle antagonist (HGF/NK4) for hepatocyte growth factor. Oncogene 17: 3045-3054, 1998.